Douglas K. Rex, MD reviewing Komaki Y et al. Gastrointest Endosc 2016 Dec 20.

All causes of chronic liver disease were associated with increased risk pre- and posttransplant.

Gastroenterologists are familiar with the increased risk for colorectal cancer (CRC) in patients with primary sclerosing cholangiopathy (PSC), which requires annual colonoscopy regardless of the ulcerative colitis (UC) duration.

To determine the risk for CRC in patients with various chronic liver diseases, investigators performed a systematic review and meta-analysis of 50 relevant studies involving nearly 56,000 patients.

The pooled standardized incidence rate for CRC was 6.70 in patients with PSC, 2.06 in patients with chronic hepatitis and cirrhosis, and 2.16 in patients post–liver transplantation. Although all causes of chronic liver disease were associated with increased risk both before and after liver transplantation, there was a particularly high risk posttransplant in patients with autoimmune liver disease, which extended to autoimmune hepatitis and primary biliary cholangiopathy in addition to PSC.

CITATION(S):

Komaki Y et al. Risk of colorectal cancer in chronic liver diseases; a systematic review and meta-analysis. Gastrointest Endosc 2016 Dec 20; [e-pub].

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